Cisplatin physicochemical properties

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August undefined, 2024

WebThe existing literature pertinent to the physicochemical properties of cisplatin and structure activity relationships of platinum coordination complexes is reviewed. … WebCisplatin also has immunosuppressive, radiosensitizing and antimicrobial properties. The exact mechanism of action of cisplatin is not yet understood but the drug has …

Physicochemical and pharmacokinetic properties of polymeric …

Web8.24.4.3.1 Cisplatin. Cisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung … WebJul 27, 2024 · Preparation, the physicochemical assessment, and the cytotoxicity of Cisplatin-loaded mesoporous Silica nanoparticles against head and neck squamous cell carcinoma cell line July 2024 Authors:... cynthia crane body found

The assessment of physicochemical properties of Cisplatin …

WebPhysicochemical properties in relation to biological action Ionization . Ionization or ionisation is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons, often in conjunction with other chemical changes. The resulting electrically charged atom or molecule is called an ion. WebCisplatin (Cis) is the first complex of platinum that has been approved by the US Food and Drug Administration (FDA) [7]. It prevents the growth of tumor cells by activating the … WebThe NPs were optimized and their physicochemical properties were examined. In vitro cytotoxicity of NPs and their synergistic combination index (CI) analysis against HepG2 liver cancer cells were conducted. In vitro release profiles of the individual drugs in the NPs were also assessed alongside the toxicity evaluation study. billy short boot

Cisplatin - an overview ScienceDirect Topics

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WebCisplatin was conjugated to the carrier polymer using cis -aconitic acid as a linker. Results: The cisplatin-loaded polyphosphazene, named “Polycisplatin” was found to be amphiphilic in aqueous solution and self-assembled into nanoparticles with an average particle size of 18.6 nm in diameter. WebCisplatin is an intercalating agent that induces apoptosis of cancer cells, and it has been the most widely used drug in the first-line chemotherapy. However, the increase in … billy short urlWebFeb 11, 2024 · The assessment of physicochemical properties of Cisplatin complexes with purines and vitamins B group. Semantic Scholar DOI: 10.1016/j.jmgm.2024.108144 Corpus ID: 246780680 The assessment of physicochemical properties of Cisplatin complexes with purines and vitamins B group. Beata Szefler, Przemysław Czeleń, +2 … billy shoup

"WebApr 12, 2024 · Cisplatin and ciprofloxacin were used as positive controls to compare the docking results with the corresponding experimental results. 3 Results and discussion 3.1 Physicochemical properties. The designed complexes were synthesized at high yield with corresponding colors of brown and light green for Cr1 and Cr2, respectively . Solvents of ... " - Cisplatin physicochemical properties

Cisplatin physicochemical properties

Kinetics of binding properties of 5′-GMP with cisplatin under …

WebKinetics of the adduct formation of cisplatin and its hydrolysis products with 5′-GMP was investigated using capillary electrophoresis (CE) under ‘simulated physiological conditions’. Therefore, chloride ion and phosphate concentration as well as the pH were chosen comparable to intracellular conditions. WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at …

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WebCisplatin (Cis) is the first complex of platinum that has been approved by the US Food and Drug Administration (FDA) [7]. It prevents the growth of tumor cells by activating the apoptosis process through binding and cross-linking to DNA [8]. WebJan 31, 2024 · Rat NRK-52E and human HK-2 subjected to cisplatin-induced AKI were treated with four polyherbs, Injinhotang (IJ), Ucha-Shinki ... has attracted interest because of the favorable physicochemical properties of these materials, including antibacterial properties and excellent biocompatibility. Multimetallic NPs, particularly those formed by …

WebAug 12, 2016 · A couple who say that a company has registered their home as the position of more than 600 million IP addresses are suing the company for $75,000. James and Theresa Arnold, who live on a farm near ... WebDownload scientific diagram SCM image of nucleus surface of HeLa cell treated with cisplatin. from publication: Scanning Capillary Microscopy in the Study of the Effect of Cytotoxic Agents on ...

WebJan 11, 2024 · Cisplatin is a squared planar platinum (II) complex composed by a central metal atom coordinated with two chlorides and two ammonia molecules in a cis configuration (Figure 2 ). Even though the … WebJan 11, 2024 · Cisplatin is a squared planar platinum(II) complex composed by a central metal atom coordinated with two chlorides and two ammonia molecules in a cisconfiguration (Figure (Figure2).2). Even though the amines are relatively inert, the two chlorides are relatively labile ligands that are prone to nucleophilic substitution.

WebOct 12, 2024 · Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma Physicochemical and pharmacokinetic properties of polymeric films loaded with cisplatin for the treatment of malignant pleural mesothelioma Authors

WebJul 15, 2024 · Besides the well-known antibacterial effect [2] they exhibit anticancer [3], diuretic [4], hypoglycemic [5], anti-inflammatory [6], or carbonic anhydrase inhibitory [7] properties. billy shore net worthWebCapecitabine C15H22FN3O6 CID 60953 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... billy short for williamWebRecently, Cu-related nanomedicine has attracted great attention in the field of tumor therapy, largely due to their physicochemical properties and the biological effects of copper. [36] ... Cisplatin is a milestone in the field of metal complexes for cancer treatment, but because of the dose-dependent side effects of cisplatin and the presence ... cynthia crane mays canyonWebFeb 1, 2024 · The physiochemical characteristics of uncoated niosomes containing Cis and Dox (Nio-Cis-Dox) compared to alginate-coated niosomes formulation (Nio … cynthia crane obituaryWebProline is water soluble amino acid extensively used in drug delivery systems. Compounds of cobalt (Co) transition metal have potent antimicrobial and anticancer activities. However, a drug delivery system combining proline cobalt is not reported yet. For the first time, new hybrid semi-organic single crystals of proline cobalt chloride (PCC) are prepared. The … billy short frye bootsWebJul 1, 2012 · cis-Diamminedichloroplatinum (II) (cisplatin) is used against different kinds of cancers. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentrations. cynthia crane found dead billy shott nps