WebFezf2 Expression Identifies a Multipotent Progenitor for Neocortical Projection Neurons, Astrocytes, and Oligodendrocytes Chao Guo,1,3Matthew J. Eckler,1,3William L. McKenna,1Gabriel L. McKinsey,2John L.R. Rubenstein,2and Bin Chen1,* 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA … WebJun 1, 2024 · the Fezf2-CreER line for selective targeting of layer V CSNs in adult mice. Having verified the functionality of the Fezf2-CreER line, we bred it with mice carrying a conditional kinase activated (ka)Braf knock-in allele (lsl-kaBraf) (10, 21) to assess the ability of B-RAF gain-of-function to promote CST axon elongation after SCI.

Pyramidal cell types drive functionally distinct cortical …

WebJun 22, 2024 · The N-terminal region of the FEZF2 protein contains an EH1 motif, which can recruit the TLE family co-repressors (Muhr et al., 2001).A previous study reported that … WebDec 4, 2013 · Upon tamoxifen administration, the Fezf2-CreER T2 allele induces recombination of the RCE-GFP reporter only in progenitor cells and not in postmitotic … hawaiian airlines missed flight

Frontiers RNA-Sequencing Analysis Reveals a Regulatory Role for ...

WebJan 23, 2024 · Pyramidal tract and intratelencephalic neurons show distinct cortex-wide activity patterns. We used CreER lines to measure the activity of two developmentally distinct PyN types: Fezf2-CreER targeting PT neurons and PlexinD1-CreER targeting IT neurons 26, crossed with Ai162 mice 29 to achieve PyN-type-specific expression of the … WebMay 20, 2015 · We recently published a study in which we tested this model using genetic lineage tracing with the Fezf2 and Cux2 loci. This work demonstrated that: (1) Fezf2-expressing (Fezf2 +) RGCs are multipotent and sequentially generate deep and upper layer cortical projection neurons followed by macroglia and (2) RGCs marked by Cux2-CreER … WebNational Center for Biotechnology Information hawaiian airlines miles upgrade chart