Web24 de dez. de 2024 · HIF-1α Promotes the Expression of IL-6. Interleukin-6 (IL-6) is a multifunctional cytokine that participates in the progression of many kinds of malignant tumours ().IL-6 is highly expressed in the serum and ascites of patients with ovarian cancer, and its upregulation is significantly associated with the poor prognosis … Web9 de dez. de 2016 · Hypoxia inducible factor-1 (HIF-1) is a basic helix-loop-helix transcription factor that is expressed in most cells in response to hypoxia. It regulates the cellular response to oxygen deficit (hypoxia) in order to minimize tissue damage.
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