Stub1 chip

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August undefined, 2024

WebOct 15, 2024 · CHIP/Stub1 interacts with eIF5A and mediates its degradation. Cellular Signalling, Volume 26, Issue 5, 2014, pp. 1098-1104. Show abstract. eIF5A, containing the unusual amino acid hypusine, is a highly conserved protein essential for the proliferation of eukaryotic cells. Previous studies have demonstrated that the activity of eIF5A was ... WebSTUB1/CHIP was also immunoprecipitated by rabbit anti-STUB1/CHIP antibody (Product # A301-573A), which recognizes a downstream epitope. For blotting immunoprecipitated …

STUB1 Gene - GeneCards CHIP Protein CHIP Antibody

WebThe carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to … WebApr 8, 2024 · More interestingly, the E3 ubiquitin ligase STIP1 homology and U-box containing protein 1 (STUB1, also known as CHIP and encoded by STUB1) emerged as … open .rpt file without crystal reports

Recombinant PE Anti-STUB1 / CHIP antibody [EPR4447] (ab303131)

WebJul 27, 2024 · The STUB1 gene (STIP1 Homology And U-Box Containing Protein 1) encodes the CHIP protein containing tetratricopeptide repeats and a U-box that functions as a ubiquitin ligase/cochaperone, involved ... WebAug 1, 2024 · STUB1 is a chaperone-associated E3 ubiquitin ligase. Previous study has shown that single-point K30A mutation in the TPR domain abolishes the binding of STUB1 to chaperones (Hsc70 or Hsp90), which results in the attenuated STUB1-substrate interaction as well as the reduced ubiquitination of substrates ( Yonezawa et al., 2024 ). Webnote = "Funding Information: We thank Dr. Ana Maria Cuervo for providing the shRNA against Lamp2a and Atg7 lentiviral vectors, and the NIH-3T3 cells, Dr. Thilo Hagen for the wild-type and proline mutant HIF1A constructs, Dr. Cam Patterson for the wild-type and mutant STUB1 constructs, and Dr. Roland H. Wenger for the Hif1a+/+ and hif1a−/− MEFs. ipad thermal design

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STUB1 STIP1 homology and U-box containing protein 1 [ (human)]

WebAug 18, 2024 · Stub1 deletion enhances antigen processing and presentation by sensitizing tumour cells to IFNγ. (a – c) Flow cytometry analysis of cell surface MHC-I on parental, control or independent Stub1... WebSTUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 … ipad there\\u0027s a problem loading this contentWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology ... ipad theme

"WebFull gene name according to HGNC. STIP1 homology and U-box containing protein 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. STUB1 (CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. " - Stub1 chip

Stub1 chip

STUB1 Gene - GeneCards CHIP Protein CHIP Antibody

WebAug 12, 2024 · updated on. August 12, 2024. On Highway 17 about an hour north of Sault Ste. Marie, Ontario at Pancake Bay and across from Agawa Crafts & The Canadian Carver, … Web2 days ago · The E3 ligases c-Cbl and CHIP are ubiquitination regulators of BCR/ABL. 23 They induce ubiquitin-dependent degradation of mature and immature BCR/ABL, respectively, and efficiently suppress BCR/ABL-dependent leukemic growth. 23 Arsenic sulfide (As 4 S 4) has been reported to upregulate c-Cbl, to enhance the ubiquitination and …

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WebAdditionally, several heterozygous mutations in STUB1 have recently been described as a cause of autosomal dominant spinocerebellar ataxia type 48. STUB1 encodes C-terminus of HSC70-interacting protein (CHIP), which functions as an E3 ubiquitin ligase and co-chaperone and has been implicated in several neurodegenerative diseases. WebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients.

WebOct 25, 2005 · Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients. Catalytic activity S-ubiquitinyl- [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl- [acceptor protein]-L-lysine. 3 publications WebSTUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal …

WebDescription Rabbit polyclonal to STUB1/CHIP Host species Rabbit Specificity Detects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human gene including a non-specific band at 80kDa .

WebApr 4, 2024 · Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease. ipad the new oneWebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml. raised against amino acids 73-303 mapping at the C … openrtb native specWebItem Stub1 Mouse qPCR Template Standard (NM_019719) Company OriGene Technologies; Price Pricing Info Supplier Page View Company Product ... 2310040B03Rik, AW046544, CH, Chip; Primer Type Gene-specific Primers; Add to Compare List. OriGene Technologies. 9620 Medical Center Drive # 200 Rockville, Maryland 20850. United States Phone: 1-888-267 ... ipad therapyWebRecently, the carboxyl terminus of Hsp70-interacting protein (CHIP), also known as STIP1 homology and U-box containing protein 1 (STUB1), has been identified as a critical regulator of necroptosis . CHIP is a 34.5-kDa cytoplasmic protein comprising the N-terminal tetratricopeptide (TPR) domain, C-terminal U-box domain, and a central coiled-coil ... ipad thermal printerWebMar 21, 2024 · STUB1 (STIP1 Homology And U-Box Containing Protein 1) is a Protein Coding gene. Diseases associated with STUB1 include Spinocerebellar Ataxia, Autosomal … open rsc new accWebSynthetic peptide within Human STUB1/CHIP aa 1-100 (N terminal). The exact sequence is proprietary. Positive control HeLa, MCF-7, 293T and ECV-304 cell lysates; Human skeletal muscle tissue. General notes This … ipad thermal runawayWebSTUB1/CHIP is 303 amino acids (aa) in length with a predicted molecular weight of 34.8 kDa. Human STUB1/CHIP shares 97% aa sequence identity with the mouse ortholog but only 67% sequence identity with the rat … open rsrc file windows